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USC Researchers Develop Wireless Ultrasound Device for Chronic Pain

Chronic pain affects millions of Americans, with over 17 million experiencing high-impact pain that significantly disrupts daily life. The reliance on opioid medications for pain management has led to severe side effects and addiction risks. Seeking alternatives to traditional pain relief methods, USC researchers have developed a groundbreaking ultrasound device that could revolutionize chronic pain management.

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Traditional implantable electrical stimulators offer relief by blocking pain signals from reaching the brain, but they come with drawbacks such as high cost, invasive surgery, and frequent battery replacements. In response to these limitations, researchers at USC Viterbi’s Alfred E. Mann Department of Biomedical Engineering, in collaboration with the Jun Chen Group at UCLA, have introduced a game-changing solution: a flexible ultrasound-induced wireless implantable (UIWI) stimulator designed for personalized, self-adaptive chronic pain management.

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Published in Nature Electronics, this innovative device represents a significant advancement in pain therapy. Unlike conventional stimulators that are bulky and battery-powered, the UIWI stimulator is flexible, adaptable to movement, and powered wirelessly by a wearable ultrasound transmitter. By harnessing machine learning algorithms, the device can tailor treatment for each individual, offering a more effective and personalized approach to pain relief.

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The core feature of this wireless implantable stimulator is its ability to receive energy from an external ultrasound transmitter, eliminating the need for cumbersome batteries and complex wired interfaces. The device converts ultrasound waves into electrical signals through a piezoelectric element, providing deep-tissue stimulation for pain management. This wireless, self-adaptive capability sets the UIWI stimulator apart, offering a promising alternative to traditional pain management approaches.

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The UIWI stimulator functions by continuously monitoring brain signals to detect pain levels. A sophisticated AI model analyzes these signals and classifies pain into distinct levels, enabling real-time adjustments to the acoustic energy transmitted by the wearable ultrasound transmitter. This closed-loop system provides personalized and targeted pain management, offering relief to individuals suffering from chronic pain.

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Lab tests using rodent models have demonstrated the effectiveness of the UIWI stimulator in managing chronic neuropathic pain caused by mechanical and thermal stimuli. The device’s ability to reduce pain indicators significantly and provide relief to test subjects highlights its potential as a transformative solution for chronic pain management.

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Looking ahead, the researchers aim to further enhance the device’s capabilities by miniaturizing its components for less invasive implantation. Future iterations may incorporate smartphone-controlled software, enabling even more personalized and intelligent pain management solutions. By combining advanced technology with innovative design, the UIWI stimulator represents a significant step forward in the quest for effective and personalized chronic pain relief.

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