In a recent retrospective cohort study published in BMC Gastroenterology, researchers analyzed factors related to the recanalization of portal vein thrombosis (PVT) in patients with liver cirrhosis. PVT is a common complication in cirrhosis patients, affecting 5-20% of individuals. The study aimed to explore predictors of PVT recanalization to aid in accurate patient prognosis and timely treatment intervention.
The study included 82 patients with cirrhotic PVT, with 30 in the recanalization group and 52 in the non-recanalization group. The researchers found that anticoagulation therapy was the only independent protective factor for PVT recanalization, while risk factors included massive ascites, history of splenectomy, Child-Pugh B/C class, and main portal vein width. Anticoagulation therapy significantly increased the rate of PVT recanalization and decreased the rate of PVT progression without raising bleeding risks.
The findings indicated that anticoagulation therapy may improve liver function in cirrhotic patients with PVT. The study also highlighted the importance of factors such as massive ascites, splenectomy history, Child-Pugh classification, and portal vein width in predicting portal vein recanalization. The results suggested that anticoagulation is safe and effective in promoting PVT recanalization without increasing bleeding complications.
Moreover, the study compared the outcomes of patients with and without anticoagulation therapy, showing no significant difference in 2-year survival rates between the groups. Anticoagulation therapy was associated with improved liver function markers, such as Child-Pugh classification and albumin levels, indicating potential benefits for patients with cirrhotic PVT.
While the study had limitations, including its retrospective nature and sample size, it provided valuable insights into the factors influencing PVT recanalization in liver cirrhosis. The results supported the use of anticoagulation therapy as a beneficial approach in managing PVT in cirrhotic patients. Future research should focus on optimizing anticoagulation regimens and evaluating the safety of anticoagulation in patients with advanced liver disease to enhance treatment outcomes.
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