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Study Reveals Predictors of Psoriatic Arthritis Development in Psoriasis

Psoriatic arthritis (PsA) is a condition that affects individuals with psoriasis (PsO), causing musculoskeletal symptoms. A recent study published in Rheumatology by Azuaga et al. delved into the clinical and ultrasound (US) features that predict the development of PsA in PsO patients without prior musculoskeletal symptoms or systemic treatment.

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The research team conducted a retrospective analysis involving PsO patients under dermatological care. Clinical and US data were gathered at baseline and during follow-up by rheumatologists to identify potential markers associated with PsA development.

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The study included 78 PsO patients with a mean disease duration of 15.1 years, with a majority exhibiting mild PsO. Additionally, a significant proportion showed onychopathy and were overweight or obese. US assessments revealed Power Doppler grade 1 in joints, calcifications, and bursitis at the enthesis. Of the 60 patients who completed the study, over half developed musculoskeletal symptoms during the follow-up period, with higher body mass index (BMI), abdominal circumference, pain, and fatigue scores being correlated with this progression. Notably, baseline US total scores were also elevated in those who developed PsA, with a subset displaying inflammatory musculoskeletal symptoms and meeting CASPAR criteria.

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The findings underscored the potential of US-detected bursitis and baseline factors like BMI, fatigue, and pain scores in predicting the onset of PsA in PsO patients who have not undergone systemic therapy. The study’s insights shed light on the importance of early detection and monitoring in this population to facilitate timely intervention and management of PsA.

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PsA remains a challenging condition to diagnose and manage, often requiring a multidisciplinary approach involving dermatologists and rheumatologists. The utilization of US as a diagnostic tool in PsO patients without musculoskeletal symptoms represents a promising avenue for identifying individuals at risk of developing PsA, enabling proactive measures to mitigate disease progression.

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These findings contribute to the growing body of knowledge surrounding PsA and emphasize the value of incorporating US assessments into the routine care of PsO patients. By leveraging advanced imaging techniques and clinical data, healthcare providers can enhance their ability to predict and address the evolving needs of individuals with PsO at risk of developing PsA.

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